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Depression and SSRI Treatment During Pregnancy—Prioritizing Maternal Mental Health

JAMA Psychiatry 10.1001/jamapsychiatry.2026.2405

August 12, 2026 at 11:00 AM EDT

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Meaningful advances in the treatment of perinatal MDD require coordinated attention to multiple aspects of clinical care delivery and research, informed by a perspective accounting for the health needs of 2 generations. Expanding access to care—particularly in maternity, child health, and psychiatric care deserts—is a public health imperative. A structured decision-making process facilitates the provision of balanced information on the potential maternal and fetal risks of untreated or undertreated illness, the benefits of treatment, and the risks associated with SSRI exposure.

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Corresponding Author: Katherine L. Wisner, MD, MS, Developing Brain Institute, Children’s National Hospital, 111 Michigan Ave NW, Washington, DC 20010 (KWisner@childrensnational.org).

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