Changes in Genetic Contributions to ASD and ADHD by Year of Diagnosis

Has the genetic risk profile of individuals diagnosed with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) changed as diagnostic rates have increased?In this cohort study among 17 071 individuals with incident diagnosis of ASD and 20 111 individuals with incident diagnosis of ADHD, genetic contributions to ASD and ADHD diagnoses weakened over the past 2 decades.These results suggest that recent increases in ASD and ADHD diagnoses coincided with a broadening of diagnostic criteria.

Corresponding Authors: Sonja LaBianca, MD, PhD, Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Capital Region of Denmark, Amager and Hvidovre Hospital, Mental Health Center Sct. Hans, Institute of Biological Psychiatry, Bldg 134, Boserupvej 2, 4000 Roskilde, Denmark (sonja.labianca@regionh.dk); Andrew J. Schork, PhD, Institute of Biological Psychiatry, Mental Health Services, Copenhagen University Hospital, Capital Region of Denmark, Amager and Hvidovre Hospital, Mental Health Center Sct. Hans, Institute of Biological Psychiatry, Bldg 134, Boserupvej 2, 4000 Roskilde, Denmark (Andrew.Joseph.Schork@regionh.dk).

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