Glucagon-Like Peptide-1 Receptor Agonists for Obstructive Sleep Apnea

This review suggest that GLP-1 RAs offer otolaryngologists a disease-modifying adjunct for obesity-related OSA that is best positioned as complementary therapy alongside CPAP, preoperative optimization before upper airway surgery, or potentially to expand hypoglossal nerve stimulator candidacy. They are appropriate for patients with a body mass index (calculated as weight in kilograms divided by height in meters squared) greater than 30 who are CPAP-intolerant or have obesity-related comorbidities but are unlikely to benefit individuals without obesity or those with primarily anatomical obstruction. Critical evidence gaps include associations with pharyngeal critical closing pressure, drug-induced sleep endoscopy collapse patterns, and hypoglossal nerve stimulator combination therapy outcomes.

Corresponding Alexandria Harris, MD, Department of Otolaryngology–Head and Neck Surgery, University of Pittsburgh Medical Center, 203 Lothrop St, Pittsburgh, PA 15213 (harrisa8@upmc.edu).

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