Original Investigation

Incidence and Risk Factors for Progression of Pachychoroid Subtype

JAMA Ophthalmology 10.1001/jamaophthalmol.2026.3168

August 13, 2026 at 11:00 AM EDT

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In this study among a relatively small cohort of 4 different levels of pachychoroid subtype, progression to a worse level was infrequent, as was worsening of visual acuity or choroidal thickening. Neovascularization was unusual and occurred exclusively in eyes with shallow, irregular retinal pigment epithelium elevation, suggesting the importance of this imaging feature if confirmed in subsequent studies.

Corresponding Author: Chui Ming Gemmy Cheung, MBBS, MRCOphth, Singapore Eye Research Institute, Singapore National Eye Centre, 11 Third Hospital Ave, Singapore 168751, Singapore (gemmy.cheung.c.m@singhealth.com.sg).

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