Pathologic Myopia Globe Shape and Long-Term Prognosis

Do baseline 3-dimensional (3D) eye shape subtypes defined by magnetic resonance imaging (MRI) predict 15-year structural and functional prognosis in highly myopic eyes?In this cohort study, 6 distinct prognostic trajectories were identified, delineating a morphologic map of the natural history of high myopia. Nasally distorted eyes constituted the highest-risk phenotype, exhibiting faster axial elongation and choroidal thinning and substantially increased risks of myopic macular degeneration progression, visual acuity loss, and field defects.3D-MRI–based eye shape classification enables long-term prognostic stratification in high myopia, potentially guiding personalized surveillance and early intervention to prevent vision loss.

Corresponding Author: Shida Chen, MD, PhD (chenshd3@mail.sysu.edu.cn), and Wei Wang, MD, PhD (wangwei@gzzoc.com), State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangdong Basic Research Center of Excellence for Major Blinding Eye Diseases Prevention and Treatment, Sun Yat-Sen University, No. 7 Jinsui Rd, Guangzhou 510623, China.

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