Research Letter

Underlying Causes and Preventability of Hospital-Onset Sepsis Events

JAMA Network Open 10.1001/jamanetworkopen.2026.34324

September 17, 2026 at 11:00 AM EDT

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This cohort study examines the underlying causes and preventability of hospital-onset sepsis events and assesses their potential use as hospital quality and safety metrics.

Corresponding Author: Fizza Manzoor, MD, Department of Population Medicine, Harvard Pilgrim Health Care Institute, 401 Park Dr, Ste 401, Boston, MA 02215 (fmanzoor@mgh.harvard.edu).

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