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Monitoring Changes in Clinical Trial Primary Outcomes Using Large Language Models

JAMA Network Open 10.1001/jamanetworkopen.2026.34214

September 16, 2026 at 11:00 AM EDT

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This cross-sectional study investigates the prevalence of meaningful changes to the outcomes in preregistered clinical trials using large language models.

Corresponding Author: Florence T. Bourgeois, MD, MPH, Harvard-MIT Center for Regulatory Science, Harvard Medical School, 210 Longwood Ave, Boston, MA 02115 (florence_bourgeois@hms.harvard.edu).

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