Original Investigation

Respiratory Syncytial Virus–Related Hospitalizations Among Infants Receiving Nirsevimab

JAMA Network Open 10.1001/jamanetworkopen.2026.33621

September 14, 2026 at 11:00 AM EDT

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This test-negative case-control study found that administration of nirsevimab to infants had high estimated effectiveness in preventing RSV disease severity that requires hospital-based care. The results suggest that nirsevimab has the potential to reduce the burden of RSV.

Corresponding Author: Sarah A. Buchan, PhD, Public Health Ontario, 661 University Ave, 17th Floor, Toronto, Ontario M5G 1M1, Canada (sarah.buchan@oahpp.ca); Stephen B. Freedman, MDCM, MSc, Pediatrics, University of Calgary, 28 Oki Dr NW, C4-634, Calgary, Alberta T3B 6A8, Canada (stephen.freedman@albertahealthservices.ca).

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