Perioperative Management of Anticoagulation in Patients With Mechanical Heart Valves

In this retrospective cohort study, patients with MHVs experienced clinically meaningful risks of perioperative ATE and bleeding. These data do not establish a causal protective effect of postoperative bridging. However, omitting bridging in patients with MHVs was associated with a higher estimated risk of ATE in exploratory analyses and should be approached cautiously, pending stronger evidence from representative cohorts.

Corresponding Author: Joseph R. Shaw, MD, MSc, Department of Medicine, Division of Hematology, The Ottawa Hospital, General Campus, 501 Smyth Rd, Box 201A, Ottawa, ON K1H 8L6, Canada (josshaw@toh.ca).

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