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Original Investigation

Opioid Dispensing Volume and Per-Patient Intensity in Sickle Cell Disease

JAMA Network Open 10.1001/jamanetworkopen.2026.32141

September 04, 2026 at 11:00 AM EDT

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Among individuals with SCD, total opioid dispensing increased or stabilized during 2021 to 2023 after prior declines, most prominently among Medicaid beneficiaries, without broad increases in per-recipient frequency, duration, or dose. These patterns are consistent with broader distribution of opioid dispensing rather than treatment intensification among recipients.

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