Original Investigation

Probiotic Implementation and Necrotizing Enterocolitis Risk in Preterm Infants

JAMA Network Open 10.1001/jamanetworkopen.2026.31601

August 31, 2026 at 11:00 AM EDT

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In this cohort study of preterm infants, implementation of a well-characterized multistrain probiotic was associated with a reduction in NEC incidence. This finding supports the use of the studied probiotic as an effective preventive strategy for NEC, although its effects on broader mortality outcomes remain uncertain.

Corresponding Author: Chris H. P. van den Akker, MD, PhD, Department of Pediatrics-Neonatology, Emma Children’s Hospital, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, the Netherlands (c.h.vandenakker@amsterdamumc.nl).

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