Original Investigation

A Multilevel Intervention to Identify Individuals for Genetic Testing and Treatment

JAMA Network Open 10.1001/jamanetworkopen.2026.30668

August 27, 2026 at 11:00 AM EDT

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In this pilot randomized clinical trial, IGNITE-TX was feasible to deliver in a community-recruited cohort with structural barriers to care and was associated with higher CGT completion and improved informed decision-making and readiness compared with non–IGNITE-TX arms. These findings support further evaluation of IGNITE-TX as a scalable navigation model for equitable hereditary cancer care.

Corresponding Author: J. Alejandro Rauh-Hain, MD, MPH, Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, 1155 Herman Pressler, Unit 1362, Houston, TX 77030-1362 (jarauh@mdanderson.org).

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