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CCL5 Levels, Disease Progression, and Mortality in Respiratory Viral Infections

JAMA Network Open 10.1001/jamanetworkopen.2026.28987

August 13, 2026 at 11:00 AM EDT

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In this systematic review and meta-analysis of 18 observational studies, elevated CCL5 levels were associated with favorable outcomes and survival in respiratory viral infections, reflecting a competent antiviral immune response rather than pathogenic hyperinflammation. These findings suggest that CCL5 may serve as a prognostic biomarker for risk stratification.

Corresponding Author: Salvador Resino, PhD, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda- Pozuelo, Km 2.2; 28220 Majadahonda (Madrid), Spain (sresino@isciii.es).

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