Original Investigation

Plasma Alzheimer Biomarkers and Diagnostic Decision-Making in Memory Clinics

JAMA Network Open 10.1001/jamanetworkopen.2026.28864

August 13, 2026 at 11:00 AM EDT

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In this prospective diagnostic study, a BBM panel was associated with altered etiologic diagnoses in a few patients and was associated with increased diagnostic confidence overall. These findings suggest that BBM may help refine the diagnostic process within specialized academic memory clinics.

Corresponding Author: Sinthujah Vigneswaran, MD, Alzheimer Center Amsterdam, De Boelelaan 1118, 1081 HV Amsterdam, the Netherlands (s.vigneswaran@amsterdamumc.nl).

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