Original Investigation

Colorectal Cancer Mortality Following an Organized Fecal Immunochemical Test–Based Screening Program

JAMA Network Open 10.1001/jamanetworkopen.2026.26951

August 05, 2026 at 11:00 AM EDT

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In this retrospective, population-based, descriptive cohort study, organized FIT-based screening was associated with a sustained decline in CRC mortality, particularly among individuals aged 50 to 69 years. These findings support the long-term benefit of organized FIT-based screening programs as a public health strategy to reduce CRC-related mortality.

Corresponding Author: Luis Bujanda, MD, PhD (luis.bujandafernandezdepierola@osakidetza.eus), and Laura Izquierdo-Sanchez (laura.izquierdosanchez@bio-gipuzkoa.eus), Department of Liver and Gastrointestinal Diseases, Biogipuzkoa Health Research Institute–Donostia University Hospital, University of the Basque Country (UPV/EHU), Paseo Dr Beguiristain s/n, 20014 San Sebastián, Spain.

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