Antipsychotic Exposure and Pharmacologically Treated Type 2 Diabetes in Dutch Youths

Does the annual prevalence of pharmacologically treated type 2 diabetes increase after antipsychotic initiation in youth? In this cohort study of 89 991 Dutch youths aged 0 to 19 years, a design controlling for stable, person-specific confounders showed that the prevalence of pharmacologically treated type 2 diabetes increased significantly after antipsychotic initiation, reaching approximately 9 additional cases per 10 000 antipsychotic users by year 5. This elevated prevalence persisted among those with brief antipsychotic exposure. Antipsychotic initiation is associated with a rapid, sustained increase in pharmacologically treated type 2 diabetes prevalence independent of underlying time-invariant factors, emphasizing the need for routine metabolic monitoring.

Corresponding Author: Ravish Nilish Gangapersad, MSc, Department of Hospital Pharmacy, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands (r.gangapersad@erasmusmc.nl).

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