Original Investigation

Intraarterial Dexamethasone for Pain Relief After Uterine Fibroid Embolization

JAMA Network Open 10.1001/jamanetworkopen.2026.25004

July 27, 2026 at 11:00 AM EDT

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Does intraarterial dexamethasone administered during uterine fibroid embolization (UFE) reduce postprocedural pain compared with placebo? In this randomized clinical trial of 40 women undergoing UFE, intraarterial dexamethasone was associated with significantly lower postprocedural pain compared with placebo. The findings of this study suggest that targeted intraarterial corticosteroid delivery addresses acute postprocedural pain, which is a primary limitation of UFE, and represents a simple, low-cost strategy with the potential to reduce analgesic burden in appropriately selected patients.

Corresponding Author: Prasoon Mohan, MD, Department of Interventional Radiology, University of Miami Miller School of Medicine, 1150 NW 14th St, Miami, FL 33136 (prasoon.mohan@flinterventionalinstitute.com).

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