Multicenter Validation of Clinical Sepsis Phenotypes

Are the 4 clinical phenotypes of sepsis derived from Sepsis Endotyping in Emergency Care (SENECA) data generalizable across independent, international patient cohorts?In this multisite retrospective cohort study of 48 246 patient encounters, there was poor consistency between the SENECA-derived phenotypes and the phenotypes derived at 3 independent clinical sites.This study found that the 4 clinical phenotypes of sepsis derived from SENECA data lack generalizability across independent cohorts, suggesting that they may not be suitable for universal clinical application in their current form.

Corresponding Authors: Chang Ho Yoon, DPhil, MB, BChir, Nuffield Department of Medicine, University of Oxford, Henry Wellcome Building for Molecular Physiology, Old Road, Oxford, OX37BN, United Kingdom (changho.yoon@ndm.ox.ac.uk); Pontus Nauclér, MD, PhD, Division of Infectious Diseases, Department of Medicine, Karolinska Institutet, Solna, K2 Infekt Naucler P, 171 77 Stockholm, Sweden (pontus.naucler@ki.se).

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