Original Investigation

User-Directed vs Interruptive Real-Time Benefit Tools for Medication Changes in Primary Care

JAMA Network Open 10.1001/jamanetworkopen.2026.15767

June 01, 2026 at 11:00 AM EDT

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What is the association of a redesign of an electronic health record real-time benefit tool (RTBT) display from user-directed to interruptive with RTBT display and medication order change frequencies?In this cohort study of 156 405 primary care encounters for 39 788 patients with multimorbidity from 2022 through 2023, the interruptive redesign was associated with a 9.62 times increase in RTBT display frequency and an 8.37 times increase in medication order changes.These findings suggest that RTBT design may play an important role in determining its potential impact on cost-related prescription medication choices during primary care encounters.

Corresponding Author: Caroline E. Sloan, MD, MPH, Division of General Internal Medicine, Duke University School of Medicine, 710 W Main St, 1st Floor, PO Box 104427, Durham, NC 27701 (caroline.sloan@duke.edu).

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