Research Letter

Heart Failure Trajectories After Guideline-Directed Medical Therapy

JAMA Network Open 10.1001/jamanetworkopen.2026.13955

May 21, 2026 at 11:00 AM EDT

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This cohort study examines left ventricular ejection fraction trajectories after an index transthoracic echocardiogram and their associations with patient characteristics and guideline-directed medical therapy use.

Corresponding Author: Brianna M. Goodwin Cartwright, MS, Truveta, Incorporated, 1745 114th Ave SE, Bellevue, WA 98004 (briannac@truveta.com).

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