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Epidemiologic Study of Transfusion-Related Alpha-Gal Syndrome

JAMA Internal Medicine 10.1001/jamainternmed.2026.3983

August 24, 2026 at 11:00 AM EDT

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This cohort study provides provocative epidemiologic evidence that TRAGS may be a unique manifestation of AGS and a previously unrecognized risk associated with transfusion. In AGS high-prevalence regions, blood collectors and hospital transfusion services should consider approaches to preventing severe ATRs from B or AB plasma or platelet units.

Corresponding Author: Richard M. Kaufman, MD, Dartmouth Hitchcock Medical Center, One Medical Center Dr, Lebanon, NH 03756 (richard.m.kaufman@hitchcock.org).

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