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Timing of Initiation of Methadone Take-Home Dosing

JAMA Internal Medicine 10.1001/jamainternmed.2026.3904

September 08, 2026 at 11:00 AM EDT

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Results of this study suggest that initiating take-home methadone within 5 to 12 weeks and 13 to 24 weeks after completing induction resulted in the greatest benefits in reducing mortality and treatment discontinuation, although any take-home dosing was consistently better than no take-home dosing. These client-level benefits warrant consideration when refining clinical guidelines on take-home dosing.

Corresponding Author: Bohdan Nosyk, PhD, Faculty of Health Sciences, Simon Fraser University, 8888 University Dr, Burnaby, BC V5A 1S6, Canada (bnosyk@sfu.ca).

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