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Serologic Immunity to Hepatitis A and B in US Adults and High-Risk Populations

JAMA Internal Medicine 10.1001/jamainternmed.2026.3831

August 17, 2026 at 11:00 AM EDT

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This cross-sectional study found that population-level serologic immunity to HAV and HBV was suboptimal and substantial susceptibility persisted across high-risk clinical subgroups. These findings highlight persistent gaps in viral hepatitis protection and support targeted, systematic vaccination strategies for HAV and HBV, especially among high-risk populations.

Corresponding Author: Giovanni A. Roldan, MD, Division of Gastroenterology, Hepatology and Nutrition, University of Minnesota, 420 Delaware St SE, MMC 36, Minneapolis, MN 55455 (rolda034@umn.edu).

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