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Comparison of Pleomorphic Dermal Sarcoma to Advanced Cutaneous Squamous Cell Carcinoma and Soft-Tissue Sarcoma

JAMA Dermatology 10.1001/jamadermatol.2026.3297

September 02, 2026 at 11:00 AM EDT

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In this cohort study, PCA analysis of single-nucleotide variants and comparison of TMB, UV signature, and pathway-level alterations between groups suggested similar genetic profiling between metastatic CSCC and PDS, which were distinct from STS.

Corresponding Author: Emily S. Ruiz, MD, MPH, Department of Dermatology, Brigham and Women’s Hospital, 1153 Centre St, Ste 4J, Boston, MA 02130 (esruiz@bwh.harvard.edu).

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