AI-Identified Reasons for Nonescalation of Lipid-Lowering Therapy for Secondary Prevention

Results of this study show that after using a state-of-the art LLM, nearly 9 in 10 ASCVD encounters with above-goal LDL-C level did not have patient LLT escalated, most often because of adverse effects, patient preference, preference for lifestyle changes, therapeutic inertia (eg, repeat laboratory tests), and near-goal LDL-C level. These findings highlight an avenue for personalizing system-level digital health interventions to help discover and minimize guideline-discordant care gaps in secondary prevention of ASCVD.

Corresponding Author: Fatima Rodriguez, MD, MPH, Center for Academic Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Mail Code 5687, 453 Quarry Rd, Palo Alto, CA 94304 (frodrigu@stanford.edu).

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