Original Investigation

Prognostic Thresholds of Tricuspid Regurgitation in Transthyretin Amyloid Cardiomyopathy

JAMA Cardiology 10.1001/jamacardio.2026.3803

August 31, 2026 at 6:15 AM EDT

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In this multicenter cohort study among patients with ATTR-CM, a validated, risk-based conceptual framework of echocardiographic parameters to quantify TR improved prediction of mortality and HFH over standard classification of TR severity, better reflecting restrictive low-flow pathophysiology and supporting disease-specific TR grading in ATTR-CM.

Corresponding Author: Christian Nitsche, MD, PhD, Clinical Division of Cardiology, Department of Internal Medicine II, Medical University of Vienna, Waehringerguertel 18-20, 1090 Vienna, Austria (christian.nitsche@meduniwien.ac.at).

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