Myocardial Fibrosis and Reverse Remodeling After Valve Replacement in Chronic Aortic Regurgitation

In this study, AVR was associated with substantial reverse remodeling at 7 months, including regression of hypertrophy and a fall in indexed extracellular (matrix) volume; the extracellular volume fraction rose, as cellular regression outpaced matrix regression. Focal scar, as a proportion of myocardium, was unchanged. Preoperative focal scar was independently associated with less recovery and may mark incomplete remodeling. Objective functional recovery did not improve at this time point.

Corresponding Author: Thomas A. Treibel, PhD, Barts Heart Centre, St Bartholomew’s Hospital, West Smithfield, London EC1A 7BE, United Kingdom (thomas.treibel.12@ucl.ac.uk).

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