Adult Male Hypogonadism

Primary hypogonadism affects less than 1% of men, whereas secondary hypogonadism due to obesity (body mass index ≥30) occurs in 2% to 8%. First-line treatment for obesity-induced hypogonadism is weight loss. Testosterone therapy should be initiated for men with permanent hypogonadism or those who are unable to discontinue medications that cause hypogonadism.

Corresponding Author: Bradley D. Anawalt, MD, Department of Medicine, University of Washington School of Medicine, 1959 NE Pacific St, Box 356420, Seattle, WA 98195 (banawalt@medicine.washington.edu).

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