Original Investigation

Electrocardiogram-Based Deep Learning to Prioritize Testing for Transthyretin Amyloid Cardiomyopathy

JAMA 10.1001/jama.2026.16785

August 28, 2026 at 7:15 AM EDT

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Locally deployable AI applied to ECG images discriminated ATTR-CM across multinational retrospective and screening cohorts. This approach may provide an accessible first step to prioritize selected patients for echocardiography and confirmatory imaging, although intended use and calibration require prospective evaluation.

Meeting Information: ESC 2026

This paper will be presented during European Society of Cardiology Congress in Munich, Germany.

Local Embargo Time: 13:15 (1:15 P.M.) CEST.

ESC Presentation: Philip Croon will present the findings during an ePoster round, “State-of-the-art in artificial intelligence for electrocardiography research,” at Exchange Circle 6 in the Research Gateway.

Corresponding Author: Rohan Khera, MD, MS, Yale School of Medicine, 100 Church St S, Ste F250, New Haven, CT 06519 (rohan.khera@yale.edu).

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