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Initial HIV Therapy for Adults and Treatment-Associated Weight Gain

JAMA 10.1001/jama.2026.14762

July 31, 2026 at 10:00 AM EDT

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Among predominantly Black African adults initiating ART, a regimen with doravirine, lamivudine, and tenofovir disoproxil fumarate was noninferior to a regimen with dolutegravir, emtricitabine, and tenofovir alafenamide for 48-week viral suppression and was associated with less weight gain.

Meeting Information:

This paper will be presented at International Aids Society (IAS).

Corresponding Author: Joana Woods, MBChB, MPH, Wits Ezintsha, Faculty of Health Sciences, University of the Witwatersrand, 32 Princess of Wales Terr, Johannesburg, South Africa 2193 (jwoods@ezintsha.org).

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