Review

Gastroparesis

JAMA 10.1001/jama.2026.12181

July 22, 2026 at 11:05 AM EDT

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Gastroparesis is a condition of delayed gastric emptying without gastric outlet obstruction that is diagnosed based on a gastric emptying study. First-line treatments include a small particle diet and antiemetics and prokinetics. Severe refractory gastroparesis may be treated with procedures such as G-POEM or gastric electrical simulation.

Corresponding Author: Michael Camilleri, MD, DSc, Mayo Clinic, Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, 200 First St SW, Charlton Bldg, Rm 8-110, Rochester, MN 55905 (camilleri.michael@mayo.edu).

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