Editor's Pick Original Investigation

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

JAMA 10.1001/jama.2026.10247

August 05, 2026 at 11:00 AM EDT

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Among comatose survivors of out-of-hospital cardiac arrest treated with therapeutic hypothermia at 33 °C, increasing cooling duration did not improve neurological outcomes.

Corresponding Author: Robert Silbergleit, MD, SIREN Clinical Coordinating Center, Department of Emergency Medicine, University of Michigan, 24 Frank Lloyd Wright Dr, Lobby H, Ste 3100, Ann Arbor, MI 48105 (robert.silbergleit@umich.edu).

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