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Residential Therapy With Navigated Transcranial Magnetic Stimulation for Combat-Related PTSD
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Trends and Disparities in the Use of Next-Generation Sequencing in Patients With Cancer in the US
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, APRIL 7, 2026
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.5585?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040726
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, most patients with advanced or metastatic cancers did not undergo tumor genomic testing. Low socioeconomic status, Black race or Hispanic ethnicity, and Medicaid or Medicare coverage were associated with significantly longer time to next-generation sequencing, highlighting the need for awareness and health care policies aimed at bridging these gaps.
Corresponding Authors: To contact the corresponding authors, email Umang Swami, MD, MS (umang.swami@hci.utah.edu) and Neeraj Agarwal, MD (neeraj.agarwal@hci.utah.edu).
(doi:10.1001/jamanetworkopen.2026.5585)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Intracranial Pressure Treatment Thresholds in Pediatric Traumatic Brain Injury
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2026.0197?guestAccessKey=24fd0ae5-6dea-47ad-9a93-3c24c8757406&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040626
A Cross-National Analysis of Suicide Among Children Ages 5 to 9
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Out-of-Pocket Spending for Insulin by Medicare Beneficiaries After Monthly Caps
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, APRIL 6, 2026
Media advisory: The full study and editorial are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2026.0255?guestAccessKey=77f4f72a-d196-41e2-b9c6-2e1596dc54ec&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040626
About The Study: In this cohort study, a $35 monthly insulin out-of-pocket cap was found to be associated with significantly lower insulin out-of-pocket spending, increased access to insulin, and decreased blood glucose levels among Medicare beneficiaries with type 2 diabetes. These findings suggest federal cost-sharing policies could improve access and adherence to essential medications in diabetes and other chronic diseases.
Corresponding Author: To contact the corresponding author, Benjamin N. Rome, MD, MPH, email brome@bwh.harvard.edu.
(doi:10.1001/jamainternmed.2026.0255)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Manufacturer-Sponsored Coupon Use and Brand-Name Drug Costs Among Patients With Insurance
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, APRIL 6, 2026
Media advisory: The full study is linked to this news release.
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About The Study: Among patients with commercial insurance, manufacturer-sponsored coupon use declined substantially between 2017 and 2024, whereas per-claim coupon amounts increased. These patterns may reflect several mechanisms. Manufacturers may be concentrating coupon programs on fewer products or for fewer patients while offering larger incentives in response to formulary pressures or expanded copay accumulator programs. Greater coupon amounts may also reflect higher underlying patient cost-sharing requirements.
Corresponding Author: To contact the corresponding author, So-Yeon Kang, PhD, MBA, email soyeon.kang@georgetown.edu.
(doi:10.1001/jama.2026.2620)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Medicare Spending Implications for Semaglutide Under Voluntary Price Agreements
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 2, 2026
Media advisory: The full study and a Viewpoint are linked to this news release.
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About The Study: This analysis suggests that the lower semaglutide price of $245 per month established under the Centers for Medicare & Medicaid Services (CMS) Innovation Center demonstration project—the Better Approaches to Lifestyle and Nutrition for Comprehensive Health (BALANCE) model could generate savings that would offset the cost of treating an additional 550,000 to 3.6 million Medicare beneficiaries eligible for expanded obesity-indication coverage, depending on assumptions about baseline use and further price reductions.
Corresponding Author: To contact the corresponding author, Stacie B. Dusetzina, PhD, email s.dusetzina@vanderbilt.edu.
(doi:10.1001/jama.2026.2615)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Unionization, Ownership Status, and Direct Care Worker Turnover
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, APRIL 2, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.4636?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040226
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of direct care workers (DCWs), employer ownership status and unionization were independently and jointly associated with DCW workforce turnover rates, suggesting that these structural factors may play an important role in DCW retention. State and federal policies that facilitate DCW unionization or public employment of DCWs may significantly improve DCW retention. Direct care workers—a broad workforce that includes home health aides, certified nursing assistants, and personal care aides—provide essential support for older adults and individuals with disabilities in the home, nursing homes, and hospital settings.
Corresponding Author: To contact the corresponding author, Geoffrey M. Gusoff, MD, MBA, MS, email ggusoff@mednet.ucla.edu.
(doi:10.1001/jamanetworkopen.2026.4636)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Advertising Payments to News Websites That Publish Health Misinformation
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 1, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.5068?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040126
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: From 2021 to 2024, government and health organizations accounted for about one-tenth of the $336 million in estimated advertising payments made to 11 news websites identified for publishing health misinformation. Noteworthy advertisers included federal health agencies, such as the Centers for Disease Control and Prevention, and pharmaceutical companies, such as Pfizer, although their individual contributions represented a small share of all payments.
Corresponding Author: To contact the corresponding author, Joseph S. Ross, MD, MHS, email joseph.ross@yale.edu.
(doi:10.1001/jamanetworkopen.2026.5068)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Mirtazapine for Methamphetamine Use Disorder
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, APRIL 1, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapsychiatry/fullarticle/10.1001/jamapsychiatry.2026.0159?guestAccessKey=5b29a34d-b21f-47c0-83b7-f23179905ee2&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=040126
About The Study: In this parallel-group randomized clinical trial, the generic tetracyclic antidepressant mirtazapine delivered in routine clinical practice reduced methamphetamine use in adults with methamphetamine use disorder. No unexpected safety concerns delivering mirtazapine in this setting were found; this finding has important clinical implications in the absence of any approved pharmacotherapies for methamphetamine use disorder.
Corresponding Author: To contact the corresponding author, Rebecca McKetin, PhD, email r.mcketin@unsw.edu.au.
(10.1001/jamapsychiatry.2026.0159)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Changes in Clinician Time Expenditure and Visit Quantity With Adoption of AI–Powered Scribes
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, APRIL 1, 2026
Media advisory: The full study and editorial are linked to this news release.
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About The Study: AI scribe adoption was associated with modest decreases in total electronic health record time and documentation time and with a modest increase in weekly visit volume.
Corresponding Author: To contact the corresponding author, Lisa S. Rotenstein, MD, MBA, MSc, email Lisa.Rotenstein@ucsf.edu.
(doi:10.1001/jama.2026.2253)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Postacute Sequelae Following Omicron COVID-19 in Patients With Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 31, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this cohort study suggest that among highly boosted patients with cancer, the overall risk of postacute sequelae following Omicron SARS-CoV-2 infection was not significantly elevated compared with noninfected patients; however, patients who were hospitalized for COVID-19 remained at increased risk of postacute sequelae despite administration of COVID-19 therapeutics. These findings further suggest that COVID-19 vaccination and boosting remain important in mitigating the risk of long COVID among immunocompromised patients during endemicity.
Corresponding Author: To contact the corresponding author, Liang En Wee, MPH, email ian.wee.l.e@singhealth.com.sg.
(doi:10.1001/jamanetworkopen.2026.4037)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1 Receptor Agonists and Noncardiometabolic Outcomes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 31, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.4722?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=033126
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this umbrella review of meta-analyses, evidence for most noncardiometabolic outcomes associated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) was of lower certainty. Potential safety signals were observed for gastrointestinal adverse events, while suggested protective associations with respiratory diseases and serious infections require further confirmation.
Corresponding Authors: To contact the corresponding authors, email Yongze Li, PhD, (yzli87@cmu.edu.cn) and Qiqiang Guo, PhD, (qqguo@cmu.edu.cn).
(doi:10.1001/jamanetworkopen.2026.4722)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long-Term Durability of Acoramidis Efficacy in Transthyretin Amyloid Cardiomyopathy
JAMA Cardiology
EMBARGOED FOR RELEASE: 2:45 P.M. (ET), MONDAY, MARCH 30, 2026
Media advisory: The full study is linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.0819?guestAccessKey=9fcaf64c-f39e-42ed-b78d-3237e6eb30e8&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=033026
About The Study: In this open-label extension of the ATTRibute-CM randomized clinical trial, early and continuous acoramidis treatment resulted in sustained incremental reductions in all-cause mortality, cardiovascular-related mortality, and first cardiovascular hospitalization through month 54. These findings support the importance of early and continuous long-term treatment with acoramidis in transthyretin amyloid cardiomyopathy (ATTR-CM).
Corresponding Author: To contact the corresponding author, Prem Soman, MD, PhD, email somanp@upmc.edu.
(doi:10.1001/jamacardio.2026.0819)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Pregnancy-Associated Spontaneous Coronary Artery Dissection
JAMA Cardiology
EMBARGOED FOR RELEASE: 4:30 P.M. (ET), SUNDAY, MARCH 29, 2026
Media advisory: The full study is linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.1009?guestAccessKey=a9dc6f76-fa12-4f15-90f3-c4c512255c81&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032926
About The Study: From this large, multisite registry, results reveal that women with pregnancy-associated spontaneous coronary artery dissection (P-SCAD) had greater median ages at gestation, greater history of assisted reproductive technology use, and greater instances of multigravida and preeclampsia than women with non–pregnancy-associated SCAD (NP-SCAD) and the general reproductive-aged U.S. population. With high percentages of vascular imaging among
participants, women with P-SCAD had less fibromuscular dysplasia but similar rates of extracoronary abnormalities including dissection and aneurysms as women with NP-SCAD. In this contemporary cohort, women with P-SCAD continue to represent a higher-risk phenotype with predominantly conservative management; however, they had less left ventricular ejection fraction recovery.
Corresponding Author: To contact the corresponding author, Agnes Koczo, MD, MS, email koczoa@upmc.edu.
(doi:10.1001/jamacardio.2026.1009)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Extended Low-Dose Apixaban and Superficial Vein Thrombosis
JAMA Cardiology
EMBARGOED FOR RELEASE: 1:40 P.M. (ET), SUNDAY, MARCH 29, 2026
Media advisory: The full study is linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.0151?guestAccessKey=3692fc98-5e98-416f-bd42-7e62e230b586&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032926
About The Study: Extended low-intensity anticoagulation with apixaban was associated with a reduction in symptomatic superficial vein thrombosis (SuVT) in patients with provoked venous thromboembolism with enduring risk factors for recurrence. Further randomized clinical trials specifically focused on SuVT are needed to ascertain optimal antithrombotic strategies in broader populations at risk of SuVT.
Corresponding Author: To contact the corresponding author, Gregory Piazza, MD, MS, email gpiazza@bwh.harvard.edu.
(doi:10.1001/jamacardio.2026.0151)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Serum Neurofilament Light Chain and Cardiovascular Outcomes in Patients With Atrial Fibrillation
JAMA Cardiology
EMBARGOED FOR RELEASE: 1:30 P.M. (ET), SUNDAY, MARCH 29, 2026
Media advisory: The full study is linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.0922?guestAccessKey=0bd507ab-f057-4396-9302-5ff00ce8819f&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032926
About The Study: After multivariable adjustment, serum neurofilament light chain (sNfL) levels were associated with a broad range of adverse cardiovascular events and mortality in patients with atrial fibrillation (AF). Serum NfL may serve as a biomarker of cardiovascular risk in patients with AF.
Corresponding Author: To contact the corresponding author, David Conen, MD, MPH, email david.conen@phri.ca.
(doi:10.1001/jamacardio.2026.0922)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure
JAMA Cardiology
EMBARGOED FOR RELEASE: 3:00 P.M. (ET), SATURDAY, MARCH 28, 2026
Media advisory: The full study and editor’s note are linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.0682?guestAccessKey=025ea14e-3c50-4cda-a5c1-5970c9d3511d&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032826
About The Study: The results of this post hoc analysis of the Finerenone Trial to Investigate the Efficacy and Safety Superior to Placebo in Patients With Heart Failure (FINEARTS-HF) randomized clinical trial reveal that in this contemporary heart failure with mildly reduced ejection fraction or heart failure with preserved ejection fraction cohort, sudden death was preceded by modest worsening of symptoms, declining quality of life, and rising natriuretic peptide levels, suggesting many of these events may not have been entirely sudden. However, similar deterioration preceding other modes of death suggests limited specificity for sudden death.
Corresponding Author: To contact the corresponding author, Scott D. Solomon, MD, email ssolomon@bwh.harvard.edu.
(doi:10.1001/jamacardio.2026.0682)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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EMPEROR-Preserved Risk Model and Outcomes in the FINEARTS-HF Trial
JAMA Cardiology
EMBARGOED FOR RELEASE: 3:00 P.M. (ET), SATURDAY, MARCH 28, 2026
Media advisory: The full study is linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.1049?guestAccessKey=b7cc855d-7727-437c-afd4-a567b0b078f6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032826
About The Study: The Empagliflozin Outcome Trial in Patients With Chronic Heart Failure With Preserved Ejection Fraction (EMPEROR-Preserved) risk models demonstrated good performance in Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients With Heart Failure (FINEARTS-HF). Baseline risk did not modify the relative treatment effect of finerenone.
Corresponding Author: To contact the corresponding author, John J. V. McMurray, MD, email john.mcmurray@glasgow.ac.uk.
(doi:10.1001/jamacardio.2026.1049)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Cardiorenal Outcomes With Tirzepatide Compared With Dulaglutide in Patients With Diabetes and Cardiovascular Disease
JAMA Cardiology
EMBARGOED FOR RELEASE: 2:30 P.M. (ET), SATURDAY, MARCH 28, 2026
Media advisory: The full study and editor’s note are linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamacardiology/fullarticle/10.1001/jamacardio.2026.0767?guestAccessKey=9d185a50-119b-4cb8-a1eb-05fd89318415&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=032826
About The Study: In this post hoc analysis, the dual glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide agonist tirzepatide, compared with the GLP-1 agonist dulaglutide, was associated with a lower incidence of a broad 6-component composite cardiovascular and kidney end point in patients with diabetes and established cardiovascular disease.
Corresponding Author: To contact the corresponding author, Steven E. Nissen, MD, email nissens@ccf.org.
(doi:10.1001/jamacardio.2026.0767)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Evolocumab to Reduce First Major Cardiovascular Events in Patients Without Known Significant Atherosclerosis and With Diabetes
JAMA
EMBARGOED FOR RELEASE: 4:45 P.M. ET, SATURDAY, MARCH 28, 2026
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the American College of Cardiology 75th Annual Scientific Session & Expo.
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About The Study: In high-risk patients without known significant atherosclerosis and with diabetes, evolocumab reduced the risk of a first major cardiovascular event.
Corresponding Author: To contact the corresponding author, Nicholas A. Marston, MD, MPH, email nmarston@bwh.harvard.edu.
(doi:10.1001/jama.2026.3277)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Lead-Attributable Cardiovascular Disease Burden
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 30, 2026
Media advisory: The full study and editorial are linked to this news release.
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About The Study: A longitudinal analysis of 42,000 National Health and Nutrition Examination Survey participants and meta-analysis found higher bone lead levels associated with significantly increased cardiovascular disease mortality risk. Globally in 2023, 3.5 million deaths and 71.6 million disability-adjusted life-years (DALYs) were attributable to lead exposure, accounting for 5.8% of all deaths and 2.6% of all DALYs. Strengthened surveillance, regulation, and remediation are urgently required to reduce the lead-attributable burden.
Corresponding Author: To contact the corresponding author, Jeffrey D. Stanaway, MPH, PhD, email stanaway@uw.edu.
(doi:10.1001/jama.2026.2197)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Lasting Income Costs of Mental and Physical Illness
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MARCH 27, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This study estimated income losses from the individual perspective in the 10 years following hospital diagnosis of depression, alcohol use disorder, stroke, and breast cancer from 2000 to 2023 in Denmark. The researchers found that (1) income losses following mental disorder diagnoses were larger than those for physical conditions, though all evaluated diseases led to substantive loss; (2) average losses grew in years following diagnosis, particularly among individuals younger than 40 and those in school, suggesting accumulating disadvantage; and (3) even those outside of the workforce at the time of hospital diagnosis experienced sustained future income loss.
Corresponding Author: To contact the corresponding author, Emily K. Johnson, MSc, email ejohnson@health.sdu.dk.
(doi:10.1001/jamahealthforum.2026.0196)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Geographic Shifts in Early-Stage Biopharmaceutical Innovation
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MARCH 26, 2026
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About The Study: Global early-stage drug development has nearly doubled over the past decade, shifting from a system dominated by the U.S. toward a 2-hub structure centered on the U.S. and China. Because early-stage drug candidates shape future drug approvals and investment, these shifts may have downstream implications for regulatory coordination, scientific workforce development, and patient access to new therapies. Continued monitoring will be essential for policymakers to understand these consequences and to design appropriate financial and regulatory incentives.
Corresponding Author: To contact the corresponding author, So-Yeon Kang, PhD, MBA, email soyeon.kang@georgetown.edu.
(doi:10.1001/jama.2026.1962)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Obesity Control’s Underestimated Potential for Cancer Prevention
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MARCH 26, 2026
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About The Article: This Viewpoint discusses obesity prevention and control as an underestimated and underutilized strategy in the prevention of numerous cancers.
Corresponding Author: To contact the corresponding author, Hermann Brenner, MD, email h.brenner@dkfz.de.
(doi:10.1001/jamaoncol.2026.0032)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Surgeons Sponsored for H-1B Visas in the US
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 25, 2026
Media advisory: The full study is linked to this news release.
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About The Study: The number of surgeons sponsored for H-1B visas increased over the past decade, reaching more than 650 in a single year in FY2024. Although H-1B–sponsored surgeons represent a small fraction of the national surgical workforce, they are overrepresented in underserved communities. For example, the percentage of H-1B–sponsored surgeons was more than twice as high in rural compared with urban counties and more than 4 times as high in the most vs least impoverished counties.
Corresponding Author: To contact the corresponding author, Thomas C. Tsai, MD, MPH, email ttsai@bwh.harvard.edu.
(doi:10.1001/jamasurg.2026.0484)
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Prospective Evidence on AI−Assisted Melanoma Diagnostics
JAMA Dermatology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 25, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In the systematic review and meta-analysis of prospective settings, AI systems perform at comparable levels to dermatologists for melanoma diagnostics and may enhance performance when used as a decision-support tool. However, the frequent risk of bias and limited generalizability of current studies highlight the need for broader validation in unselected patient populations in the clinical setting.
Corresponding Author: To contact the corresponding author, Titus J. Brinker, MD, email titus.brinker@dkfz.de.
(doi:10.1001/jamadermatol.2026.0217)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Evaluation of Large Language Model Chatbot Responses to Psychotic Prompts
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 25, 2026
Media advisory: The full study is linked to this news release.
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About The Study: All 3 versions of ChatGPT tested in this study showed high rates of inappropriate or partially appropriate responses to psychotic prompts with overlapping confidence intervals. In the across-version analysis, GPT-5 did perform better than the free product that most users interact with. This is notable because individuals with psychosis risk may be overrepresented among the economically disadvantaged.
Corresponding Author: To contact the corresponding author, Amandeep Jutla, MD, email aj2843@cumc.columbia.edu.
(10.1001/jamapsychiatry.2026.0249)
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GH001 vs Placebo in Patients With Treatment-Resistant Depression
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 25, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In this study, an individualized dosing regimen of GH001, a synthetic inhaled formulation of mebufotenin, resulted in significant improvements in depression symptoms relative to placebo and was well tolerated, supporting its potential as a novel, rapid-acting treatment for treatment-resistant depression.
Corresponding Author: To contact the corresponding author, Michael E. Thase, MD, email thase@pennmedicine.upenn.edu. Other co-authors available to interview: Wiesław J. Cubała, MD, PhD, (wieslaw.j.cubala@gumed.edu.pl); Bernhard T. Baune,MD, PhD, MPH, MBA, (bernhard.baune@uni-muenster.de); Andreas Reif, MD, (reif@med.uni-frankfurt.de); Velichka Valcheva, MD, (vv@ghres.com).
(10.1001/jamapsychiatry.2026.0096)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Atopic Dermatitis and Markers of Early Cardiovascular Risk in Children and Adolescents
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Slow-Release Oral Morphine vs Methadone for Opioid Use Disorder in the Fentanyl Era
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Moral Distress and Occupational Burnout in US Physicians
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Kindergarten Screening for Early (Grade 1) and Late-Emerging (Grade 4) Dyslexia Risk
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 24, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of 515 children followed from kindergarten through grades 1 and 4, distinct patterns of cognitive-linguistic deficits in kindergarten were associated with 2- to 5-fold increased risk for early- and late-emerging dyslexia. These findings provide a foundational evidence base to support the integration of developmentally sensitive screening into pediatric surveillance frameworks, facilitating early identification and a shift from reactive to preventive care, including for children at risk of late-emerging dyslexia.
Corresponding Authors: To contact the corresponding authors, email Avi Karni, MD, PhD, (avi.karni@yahoo.com) and Rotem Yinon, PhD, (rotemwr82@gmail.com).
(doi:10.1001/jamanetworkopen.2026.3036)
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Medicare Plan Switching and Hospice Care Among Decedents With Advanced Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 24, 2026
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of Medicare decedents with advanced cancers, continuous Medicare Advantage (MA) enrollees were most likely to receive hospice at home, while those who switched from MA to traditional Medicare more frequently received hospice care in nursing homes. Plan switching near the end-of-life (EOL) may reflect access barriers, highlighting the importance of addressing care coordination to improve EOL care.
Corresponding Author: To contact the corresponding author, Xin Hu, PhD, email xin.hu@emory.edu.
(doi:10.1001/jamanetworkopen.2026.0755)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Childhood Mortality by Parental Cause of Death
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 23, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This statewide cohort study found that childhood mortality is significantly higher among children bereaved by parental drug overdose, homicide, and suicide compared with the general child population. Parental homicide was associated with the highest risk of mortality in children and highlights the need for research into potential explanations, such as the impact on family restructuring and mental health.
Corresponding Author: To contact the corresponding author, Sean Esteban McCabe, PhD, email plius@med.umich.edu.
(doi:10.1001/jamanetworkopen.2026.2790)
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Alignment of Large Language Model Responses With Human Therapists in Motivational Interviewing
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 23, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest large language models (LLMs) can produce contextually appropriate motivational interviewing-consistent responses, but limitations in coherence and stylistic alignment highlight the need for further validation before clinical use. Motivational interviewing, a structured counseling approach, provides an empirically grounded setting for evaluating alignment between LLM-generated and human therapist responses.
Corresponding Author: To contact the corresponding author, Venkat Bhat, MD, MSc, email venkat.bhat@utoronto.ca.
(doi:10.1001/jamanetworkopen.2026.2750)
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Prescription Drug Promotion by Social Media Influencers
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 23, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This systematic scoping review study of prescription drug promotion by influencers found that such promotion carried risks of inaccurate or misleading advice, often amplified through personal and emotionally resonant narratives in an environment with limited oversight and enforcement. Despite the small and fragmented evidence base, these findings highlight the urgent need for updated regulatory guidance, standardized and enforceable disclosure requirements, stronger platform accountability, and targeted digital literacy initiatives. Policymakers and researchers should act proactively to safeguard public health.
Corresponding Author: To contact the corresponding author, Raffael Heiss, PhD, email raffael.heiss@mci.edu.
(doi:10.1001/jamanetworkopen.2026.2738)
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Sleep Health Dimensions From Wearables and Transdiagnostic Mental Health in Young Adolescents
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 23, 2026
Media advisory: The full study is linked to this news release.
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About The Study: Using Fitbit data in a longitudinal cohort of 3,393 young adolescents, 6 sleep health dimensions were identified: irregularity, timing, duration, social jetlag, weekend oversleep, and continuity. Greater irregularity was associated with higher concurrent transdiagnostic mental health symptoms, whereas shorter duration was associated with higher symptoms at 1-year follow-up. These findings demonstrate the multidimensional nature of adolescent sleep health and can help guide selection of sleep health domains and representative measures to enhance reproducibility and suggest potential intervention targets.
Corresponding Author: To contact the corresponding author, Meredith L. Wallace, PhD, email lotzmj@upmc.edu.
(doi:10.1001/jamapediatrics.2026.0335
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Long-Term Cardiometabolic Outcomes in Children With Metabolically Healthy and Unhealthy Obesity
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 23, 2026
Media advisory: The full study is linked to this news release.
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About The Study: The results this cohort study suggest that children ages 7 to 17 with metabolically healthy obesity at treatment initiation have an increased associated long-term risk of type 2 diabetes, hypertension, and dyslipidemia compared with their peers in the general population. Reduction in BMI z score in pediatric obesity treatment was associated with reduced cardiometabolic risk in children with metabolically healthy and unhealthy obesity to the same extent. Therefore, treatment should also be recommended for children with obesity who appear metabolically healthy.
Corresponding Author: To contact the corresponding author, Emilia Hagman, PhD, email emilia.hagman@ki.se.
(doi:10.1001/jamapediatrics.2026.0343)
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Effects of Exercise and Intensive Vascular Risk Reduction on Cognitive Function in Older Adults
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 23, 2026
Media advisory: The full study and editorial are linked to this news release.
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About The Study: In this multicenter randomized clinical trial among older adults with family history of dementia and/or self-reported subjective cognitive decline, exercise, intensive pharmacological reduction of cardiovascular risk factors, or both did not result in statistically significant differences in improvements in cognitive function over 24 months.
Corresponding Author: To contact the corresponding author, Rong Zhang, PhD, email rongzhang@texashealth.org.
(doi:10.1001/jamaneurol.2026.0359)
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Thirty-Year Trends in Multiple Sclerosis Prevalence, Lifestyle Factors, and Mortality in England
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 23, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In England’s health care system, multiple sclerosis prevalence more than doubled while survival rates increased over 30 years. Substantial gradients in tobacco use, abnormal weight, and socioeconomic deprivation persisted and were associated with mortality.
Corresponding Author: To contact the corresponding author, Raffaele Palladino, PhD, MD, email palladino.raffaele@gmail.com.
(doi:10.1001/jamaneurol.2026.0352)
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Clinician Perspectives on the Extracorporeal Membrane Oxygenation Decision-Making Process
JAMA Network Open
EMBARGOED FOR RELEASE: 1 P.M. ET, SUNDAY, MARCH 22, 2026
Media advisory: The full study is linked to this news release. This study is being presented at the Society of Critical Care Medicine Congress.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this qualitative study, decisions to pursue venovenous extracorporeal membrane oxygenation for patients with severe respiratory failure were largely based on clinical judgments of suitability rather than objective guidelines. Variability in candidacy decision-making may lead to inconsistent or inequitable allocation.
Corresponding Author: To contact the corresponding author, Derek R. Soled, MD, MBA, MSc, email dsoled@bwh.harvard.edu.
(doi:10.1001/jamanetworkopen.2026.2044)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data
JAMA
EMBARGOED FOR RELEASE: 2:30 P.M. ET, SUNDAY, MARCH 22, 2026
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the Society of Critical Care Medicine Congress.
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About The Study: An electronic health record-based definition for pediatric sepsis demonstrated strong validity compared with physician-adjudicated Phoenix sepsis and identified sepsis in 1.3% of pediatric hospitalizations with 10% mortality, corresponding to more than 18,000 cases and more than 1,800 deaths annually in the U.S.
Corresponding Author: To contact the corresponding author, Chanu Rhee, MD, MPH, email crhee@bwh.harvard.edu.
(doi:10.1001/jama.2026.3100)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Management of Hypertension in Adults
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Diagnosis and Management of Resistant Hypertension – A Review
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Tobacco Smoking and Lung Cancer Risk After Negative Baseline Low-Dose Computed Tomography Findings
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MARCH 20, 2026
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, smokers with negative baseline low-dose computed tomography findings exhibited a substantially elevated long-term lung cancer risk, which became significant only after 2 years after screening. These findings suggest support for extending the initial screening interval and implementing personalized long-term monitoring based on smoking history.
Corresponding Author: To contact the corresponding author, Shaokai Zhang, PhD, email shaokaizhang@126.com.
(doi:10.1001/jamanetworkopen.2026.1913)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Extreme Urban Heat and Emergency Department Visits in Older Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MARCH 20, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that significant heat-health risks were observed in an emergency department serving socioeconomically vulnerable populations, suggesting tailored heat warning strategies should be studied further.
Corresponding Author: To contact the corresponding author, Alexander Azan, MD, email alexander.azan@nyulangone.org.
(doi:10.1001/jamanetworkopen.2026.2645)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Insurance Churn and Diabetes Outcomes Among Patients With Low Income
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MARCH 20, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This case-control study found that insurance churn (defined as 2 or more consecutive uninsured visits, to capture sustained coverage loss) among community health center (CHC) patients with diabetes was associated with poorer diabetes management and increased insulin use and acute diabetes complications. These results underscore the harm insurance (Medicaid or private) instability could have on CHC patients with diabetes. Supporting continuous insurance coverage for patients with low income who have diabetes will likely lower risk for costly preventable diabetes complications.
Corresponding Author: To contact the corresponding author, Nathalie Huguet, PhD, email huguetn@ohsu.edu.
(doi:10.1001/jamahealthforum.2026.0034)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Colorectal Cancer Risk With Negative Colonoscopy or Nonadherence After Positive Fecal Occult Blood Test Screening
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MARCH 19, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study, a decrease in colorectal cancer (CRC) incidence was observed among individuals with negative results in screening colonoscopies, with a greater decrease in men, supporting risk-based, individualized follow-up strategies. A high-risk group for CRC was identified among individuals who did not adhere to follow-up colonoscopy, enabling targeted interventions to improve early CRC detection.
Corresponding Author: To contact the corresponding author, Hanna Heyman, MD, email hanna.heyman@ki.se.
(doi:10.1001/jamanetworkopen.2026.2404)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Warfarin Patient Self-Management in the US Health Care System
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MARCH 19, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this single-group implementation trial, warfarin patient self-management was safely and effectively implemented. These results provide critically needed evidence to facilitate and accelerate patient self-management implementation in the U.S. health care system.
Corresponding Author: To contact the corresponding author, Daniel M. Witt, PharmD, FCCP, email dan.witt@pharm.utah.edu.
(doi:10.1001/jamanetworkopen.2026.2627)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Meat Consumption and Cognitive Health by APOE Genotype
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MARCH 19, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this study, higher meat consumption was associated with better cognitive trajectories and lower dementia risk among individuals with APOE34/44 genotypes. The expected cognitive disadvantage among individuals with APOE34/44 genotypes was not observed at high meat consumption, suggesting clinical and public health relevance. The apolipoprotein E (APOE) ε4 allele increases Alzheimer disease risk.
Corresponding Author: To contact the corresponding author, Jakob Norgren, PhD, email jakob.norgren@ki.se.
(doi:10.1001/jamanetworkopen.2026.6489)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients
JAMA
EMBARGOED FOR RELEASE: 4:35 A.M. ET, TUESDAY, MARCH 17, 2026
Media advisory: The full study and editorial are linked to this news release. This study is being presented at the 45th International Symposium on Intensive Care and Emergency Medicine.
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About The Study: In this randomized clinical trial, among adult patients receiving mechanical ventilation in the intensive care unit (ICU), a low-use wrist-strap physical restraint strategy compared with a high-use strategy did not reduce days free of delirium or coma at 14 days.
Corresponding Author: To contact the corresponding author, Romain Sonneville, MD, PhD, email romain.sonneville@aphp.fr.
(doi:10.1001/jama.2026.2897)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 18, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In trials of depression, psychedelic-assisted therapy (PAT) was not more effective than open-label traditional antidepressants (TADs). Blinding made a difference for TADs, but not for PAT, confirming that PAT trials are effectively always open label. These results argue against highly optimistic narratives surrounding PAT and highlight the importance of blinding integrity.
Corresponding Author: To contact the corresponding author, Balázs Szigeti, PhD, email balazs.szigeti@ucsf.edu.
(10.1001/jamapsychiatry.2025.4809)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Premature Menopause and Lifetime Risk of Coronary Heart Disease
JAMA Cardiology
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 18, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In this cohort study, premature menopause was associated with 40% higher lifetime risk of coronary heart disease in Black and white women. This suggests that premature onset of menopause is an important risk-enhancing factor for lifetime risk and should be routinely assessed in clinical practice to consider intensification of preventive efforts.
Corresponding Author: To contact the corresponding author, Priya M. Freaney, MD, email priya.freaney@northwestern.edu.
(doi:10.1001/jamacardio.2026.0212)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflicts of interest and financial disclosures, and funding and support.
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Prevalence of Thoughts of Shooting Others Among US Adults
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Adolescent Responses to Coercive Requests for Sexual Images
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Violence Against Women Who Inject Drugs
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 17, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this mixed-methods cohort study of Australian women who inject drugs, violence against women was pervasive and severe, yet rates of seeking health care remained low likely due to intersecting structural and social barriers. Recognition of the burden of violence is a critical first step in ensuring tailored responses to violence that meet the needs of marginalized women.
Corresponding Author: To contact the corresponding author, Ashleigh Cara Stewart, PhD, email ashleigh.stewart@burnet.edu.au.
(doi:10.1001/jamanetworkopen.2026.2096)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Adherence to Healthy Lifestyle and Risk of Cardiometabolic Diseases in Individuals With Hypertension
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 17, 2026
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of individuals living with hypertension, maintaining a healthy lifestyle was associated with lower risk of major cardiometabolic diseases independent of antihypertensive medication use, underscoring the value of adopting multiple healthy lifestyle behaviors. A healthy lifestyle was defined as eating a high-quality diet, not smoking, engaging in moderate-to-vigorous-intensity physical activity, no more than moderate alcohol consumption, and having a healthy body mass index.
Corresponding Author: To contact the corresponding author, Qi Sun, MD, ScD, email qisun@hsph.harvard.edu.
(doi:10.1001/jamanetworkopen.2026.0937)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Burn Risks Among People Who Use Smokable Drugs in the Era of Butane Torches
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Geographic, Racial, and Sex Disparities in Time to Treatment for Early-Onset Colorectal Cancer
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 16, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional analysis found that delays in treatment initiation for early-onset colorectal cancer—often exceeding 90 days—were more common in all-urban populations and appeared to disproportionately affect young male, Asian or Pacific Islander, Black, or Hispanic patients. Although absolute differences in average treatment timing were modest, the focus in this study on clinically relevant delay thresholds (30, 60, and 90 days) is supported by recent meta-analytic literature. The consistency of these delays across sociodemographic groups challenges assumptions of uniformly timely access in urban settings.
Corresponding Author: To contact the corresponding author, Meng-Han Tsai, PhD, email metsai@augusta.edu.
(doi:10.1001/jamanetworkopen.2026.1980)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long-Term Trends in Pediatric Self-Injury in High-Income Countries
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 16, 2026
Media advisory: The full study is linked to this news release.
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About The Study: This systematic review and meta-analysis of 42 studies observed a relative increase in the annual rate of self-injury visits to health care and self-reported self-injury among children and youth, with variability in baseline rates across studies in 12 high-income countries. Effective, contextually informed, large-scale prevention initiatives are urgently needed to curb the rise in self-injury within high-income countries, particularly among female individuals.
Corresponding Author: To contact the corresponding author, Natasha Saunders, MD, email natasha.saunders@sickkids.ca.
(doi:10.1001/jamapediatrics.2026.0217)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy
JAMA Internal Medicine
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 16, 2026
Media advisory: The full study is linked to this news release.
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About The Study: This randomized clinical trial found that continuing glucagon-like peptide-1 (GLP-1) or glucose-dependent insulinotropic polypeptide (GIP) agonist in the preprocedural period increased clinically significant residual gastric volume (RGV) but did not increase the risk of other adverse events. Clear liquids the day prior to the procedure may mitigate the risk of clinically significant RGV regardless of GLP-1/GIP use.
Corresponding Author: To contact the corresponding author, Tilak Shah, MD, MHS, email shaht3@ccf.org.
(doi:10.1001/jamainternmed.2026.0027)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Geographic Accessibility of Deceased Organ Donor Care Units
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MARCH 13, 2026
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cohort study found that despite their reported advantages and consensus endorsement, heterogeneous adoption of donor care units (DCUs) has left a substantial proportion of deceased donors after brain death more than a 180-minute drive from a DCU. Given inefficiencies introduced by donation service area boundaries, opening additional DCUs in acute care hospitals and donor transport across these existing boundaries may be 2 potential approaches to improve system efficiency and donation outcomes.
Corresponding Author: To contact the corresponding author, Peter P. Reese, MD, PhD, email peter.reese@vumc.org.
(doi:10.1001/jamanetworkopen.2026.1703)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Recovery Experiences of Older Adults and Their Caregivers After Major Elective Noncardiac Surgery
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MARCH 13, 2026
Media advisory: The full study and commentary are linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.0692?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=031326
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this mixed-methods cohort study, functional recovery in the first 6 months after noncardiac major elective surgery was associated with daily living impairment for older adults and their caregivers. Targeted interventions including preoperative education, caregiver-inclusive discharge planning (e.g., wound-care teaching, how to recognize complications and what to do for support, and more rehabilitation), and early follow-up after discharge may optimize recovery experiences.
Corresponding Author: To contact the corresponding author, Martine Puts, RN, PhD, email martine.puts@utoronto.ca.
(doi:10.1001/jamanetworkopen.2026.0692)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Psilocybin Trends in States That Decriminalized Use
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MARCH 12, 2026
Media advisory: The full study is linked to this news release.
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About The Study: This study estimated the increase in 12-month psilocybin use in Oregon and Colorado associated with decriminalization.
Corresponding Author: To contact the corresponding author, Joshua C. Black, PhD, email joshua.black@rmpds.org.
(doi:10.1001/jama.2026.1952)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Adverse Childhood Experiences and Treatment-Resistant Depression
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, THURSDAY, MARCH 12, 2026
Media advisory: The full study and commentary are linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study, adverse childhood experience (ACE) exposure was associated with an increased risk of treatment-resistant depression even after accounting for unmeasured familial confounding. The findings highlight the importance of preventing ACEs and incorporating ACE history into clinical assessment to identify individuals with major depressive disorder who may be at elevated risk for treatment resistance.
Corresponding Author: To contact the corresponding author, Ying Xiong, PhD, MMedSc, email ying.xiong@ki.se.
(doi:10.1001/jamanetworkopen.2026.0222)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Housing Displacement, Employment Disruption, and Mental Health After the 2023 Maui Wildfires
JAMA Psychiatry
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 11, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In this cross-sectional study, wildfire exposure and its socioeconomic consequences were associated with graded increases in psychological distress extending beyond the burn zone. These findings highlight the importance of integrating mental health care, housing stability, and economic recovery as central pillars of disaster response and climate resilience strategies.
Corresponding Author: To contact the corresponding author, Ruben Juarez, PhD, email rubenj@hawaii.edu.
(10.1001/jamapsychiatry.2026.0044)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1 Receptor Agonist Use and Survival Among Patients With Type 2 Diabetes and Brain Metastases
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MARCH 11, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.1311?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=031126
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this cohort study suggest that glucagon-like peptide–1 receptor agonist (GLP-1 RA) use was associated with significant reduction in all-cause mortality among patients with cancer with brain metastases and type 2 diabetes, with generally consistent association across subgroups. These results build upon existing evidence that GLP-1 receptor activation modulates pathways relevant to neuro-oncologic health, including attenuation of neuroinflammation, preservation of blood–brain barrier integrity, and reduction of oxidative stress and mitochondrial dysfunction.
Corresponding Author: To contact the corresponding author, Chien-Min Chen, MD, PhD, 96015@cch.org.tw.
(doi:10.1001/jamanetworkopen.2026.1311)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Hospital Adoption and Pricing for Oncology Biosimilars
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Female Reproductive Cancers and the Sex Gap in Survival
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 10, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this population-level cohort study of 20 low-mortality countries, females ages 35 to 60 experienced disadvantage in cancer mortality compared with males—a consistent pattern observed across birth cohorts and over time. These findings underscore the ongoing need for action on the prevention, early detection, and treatment of early-onset female reproductive cancers.
Corresponding Author: To contact the corresponding author, Vladimir Canudas-Romo, PhD, email vladimir.canudas-romo@anu.edu.au.
(doi:10.1001/jamanetworkopen.2026.1256)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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GLP-1RA Switching and Treatment Persistence in Adults Without Diabetes
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 10, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this large cohort of adults with overweight or obesity without diabetes, fewer than 1 in 4 patients remained on any glucagon-like peptide-1 receptor agonist (GLP-1RA) after 12 months. Switching between GLP-1RA agents was common and may reflect active therapy management rather than nonengagement, particularly as new formulations and weight management agents emerge.
Corresponding Author: To contact the corresponding author, Luyu Xie, PharmD, PhD, email luyu.xie@utsouthwestern.edu.
(doi:10.1001/jamanetworkopen.2026.1272)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Wait Time Modifications for Black Transplant Candidates Affected by Race-Based Kidney Function Estimation
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Cost-Related Medication Nonadherence After the Inflation Reduction Act
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Cannabis and Mental Health – A Review
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Suicidality at Epilepsy Diagnosis and Future Treatment Resistance in Adults With Focal Epilepsy
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Sleep, Physical Activity, and Mood Among People Seeking Mental Health Care
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Maternal Acetaminophen Use and Child Neurodevelopment
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 9, 2026
Media advisory: The full study is linked to this news release.
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About The Study: The findings of this cohort study in Taiwan suggest that positive associations were observed between maternal prenatal acetaminophen prescriptions and offspring’s attention-deficit/hyperactivity disorder (ADHD) or autism spectrum disorders (ASDs) in the full cohort but not in the sibling-matched analyses. A substantial divergence in associations in the sibling bidirectional analyses indicates unaddressed sources of bias and prevents firm conclusions from being drawn using the sibling design.
Corresponding Authors: To contact the corresponding authors, email Pei-Chen Lee, PhD, (peichenlee@gs.ncku.edu.tw) and Zeyan Liew, PhD, (zeyan.liew@yale.edu).
(doi:10.1001/jamapediatrics.2026.0071)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Digital Media Use and Child Health and Development
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 9, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In this systematic review and meta-analysis, digital media use was consistently associated with risks to child and adolescent health and development, particularly for social media. These findings highlight the need for targeted, multifaceted policies and interventions to mitigate potential harms from digital media exposure.
Corresponding Author: To contact the corresponding author, Samantha Teague, PhD, email sam.teague@jcu.edu.au.
(doi:10.1001/jamapediatrics.2026.0085)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Digital Microsteps as Scalable Adjuncts for Adults Using GLP-1 Receptor Agonists
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 9, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this randomized clinical trial, a low-cost digital intervention increased expectation to adopt health behaviors among adults using glucagon-like peptide-1 receptor agonists (GLP-1RAs), with effects persisting for 2 weeks. These findings suggest a potential role for the written microsteps intervention plus short video boosters as adjuncts to pharmacotherapy. Longer trials are warranted to determine whether the behavioral expectations stimulated by such interventions may lead to sustained behavior change.
Corresponding Author: To contact the corresponding author, Maya Adam, MD, PhD, email madam@stanford.edu.
(doi:10.1001/jamanetworkopen.2026.0577)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Smartphone Use During School Hours and Association With Cognitive Control in Youths Ages 11 to 18
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 9, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: This cross-sectional study found that youths use smartphones approximately one-third of the school day; this use was associated with reduced cognitive control. These findings highlight the need for school-level policies and digital literacy programs that address not only overall screen time but also habitual smartphone-checking behaviors that fragment attention.
Corresponding Author: To contact the corresponding author, Eva H. Telzer, PhD, email ehtelzer@unc.edu.
(doi:10.1001/jamanetworkopen.2026.1092)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Seeking Abortion Care Across State Lines After the Dobbs Decision
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 9, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that people in states with abortion bans face limitations to obtaining abortion care out of state and should be supported through policy change, visible information and resources, and charitable and interpersonal social support systems.
Corresponding Author: To contact the corresponding author, Alia Cornell, MPH, email alia.d.cornell@kp.org.
(doi:10.1001/jamanetworkopen.2026.1068)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Incidence of Out-of-Hospital Cardiac Arrest on a Postholiday Weekday
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, FRIDAY, MARCH 6, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this nationwide cohort study, a postholiday weekday was associated with a significantly elevated out-of-hospital cardiac arrest incidence in South Korea, particularly after consecutive rest days and among vulnerable populations. These findings support enhanced emergency medical services preparedness, targeted public health messaging during holiday periods, and evaluation of preventive interventions for high-risk populations during postholiday transitions.
Corresponding Author: To contact the corresponding author, Myoung-Je Song, MD, email smj66@ish.ac.kr.
(doi:10.1001/jamanetworkopen.2026.0832)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Racial Disparities in Food Insecurity for High- and Low-Income Households
JAMA Health Forum
EMBARGOED FOR RELEASE: 11 A.M. (ET), FRIDAY, MARCH 6, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Health Forum: JAMA Health Forum is an international, peer-reviewed, online, open access journal that addresses health policy and strategies affecting medicine, health and health care. The journal publishes original research, evidence-based reports and opinion about national and global health policy; innovative approaches to health care delivery; and health care economics, access, quality, safety, equity and reform. Its distribution will be solely digital and all content will be freely available for anyone to read.
About The Study: This cross-sectional study builds on prior evidence by documenting intersectional disparities in food insecurity persistent over 23 years despite multiple intervening policy and macroeconomic changes. As in a prior cross-sectional study, racial disparities were smaller among Supplemental Nutrition Assistance Program (SNAP)-participating households than nonparticipating households.
Corresponding Author: To contact the corresponding author, Cordelia Kwon, MPH, email cordeliakwon@g.harvard.edu.
(doi:10.1001/jamahealthforum.2025.6935)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Outcomes of Older Adults With Advanced Cancer Who Prefer Quality of Life vs Prolonging Survival
JAMA Oncology
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MARCH 5 2026
Media advisory: The full study and editor’s note are linked to this news release.
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About The Study: In this secondary analysis of a randomized clinical trial, fewer than 1 in 10 older adults with advanced cancer participating in the trial prioritized extending survival over maintaining quality of life. Patient preference for extending survival or maintaining quality of life was not associated with up-front treatment modifications or downstream outcomes, suggesting a possible lack of responsiveness of the current oncology care delivery system to patient preference.
Corresponding Author: To contact the corresponding author, Daniel R. Richardson, MD, MSc, email daniel_richardson@med.unc.edu.
(doi:10.1001/jamaoncol.2026.0072)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Lower Music Volume Levels in Fitness Class and Perceived Exercise Intensity
JAMA Otolaryngology–Head & Neck Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), THURSDAY, MARCH 5, 2026
Media advisory: The full study is linked to this news release.
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About The Study: In this comparative effectiveness study, reducing music volume in group fitness classes did not lead to meaningful reductions in perceived exertion and may reduce the risk of noise-induced hearing loss. These findings support implementing safer sound practices in fitness environments and underscore the need for increased awareness and education on hearing protection.
Corresponding Author: To contact the corresponding author, Janet S. Choi, MD, MPH, email janet.choi@med.usc.edu.
(doi:10.1001/jamaoto.2026.0028)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Metabolic and Bariatric Surgery Use During the GLP-1 Receptor Agonist Era
JAMA Surgery
EMBARGOED FOR RELEASE: 11 A.M. (ET), WEDNESDAY, MARCH 4, 2026
Media advisory: The full study is linked to this news release.
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About The Study: Among metabolic and bariatric surgery (MBS)-eligible patients in a national sample, semaglutide and tirzepatide prescriptions increased dramatically between 2018 and 2025, whereas MBS use rates declined substantially beginning in 2023. Stratification by procedure type and body mass index (BMI) category suggests that recent shifts in MBS use may be more pronounced in certain patient subgroups (e.g., those seeking sleeve gastrectomy or with lower BMIs).
Corresponding Author: To contact the corresponding author, Stefanie C. Rohde, MD, email stefanie.rohde@osumc.edu.
(doi:10.1001/jamasurg.2026.0049)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Loneliness, Anxiety Symptoms, Depressive Symptoms, and Suicidal Ideation in the All of Us Dataset
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MARCH 4, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cross-sectional study of 62,685 participants from the All of Us Research Program, loneliness partially mediated the association between anxiety symptoms and suicidal ideation as well as depressive symptoms and suicidal ideation. Targeting and reducing loneliness may present a transdiagnostic approach to arrest the progression from anxiety and depressive symptoms toward suicidal ideation.
Corresponding Author: To contact the corresponding author, Katherine Musacchio Schafer, PhD, email katherine.m.schafer@vumc.org.
(doi:10.1001/jamanetworkopen.2026.0596)
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A Decision-Support System to Personalize Antidepressant Treatment in Major Depressive Disorder
JAMA
EMBARGOED FOR RELEASE: 11 A.M. ET, WEDNESDAY, MARCH 4, 2026
Media advisory: The full study and editorial are linked to this news release.
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About The Study: Compared with usual care, use of the PETRUSHKA tool increased the number of patients still taking their antidepressant at 8 weeks and improved depressive and anxiety symptoms at 24 weeks. However, lack of a double-blind design and the large amount of missing data limit the validity of these results. The PETRUSHKA tool is a web-based clinical decision-support system combining clinical and demographic predictors with patient preferences to personalize antidepressant treatment.
Corresponding Author: To contact the corresponding author, Andrea Cipriani, MD, PhD, email andrea.cipriani@psych.ox.ac.uk.
(doi:10.1001/jama.2026.1327)
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Understanding of Prognosis and Estimation of Mortality in Ambulatory Patients With Heart Failure
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Trauma- and Violence-Informed Care Practices in the Emergency Department for Survivors of Intimate Partner Violence
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RSV Detection and Antibiotic Prescribing Decisions for Pediatric Respiratory Tract Infections
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Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 3, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2026.0434?guestAccessKey=1b34668e-afe8-4888-aa3d-dd05b3b83eff&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=030326
About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In this cohort study of preschoolers in Canada, higher ultraprocessed foods (UPF) intake was associated with adverse behavioral and emotional symptoms by age 5. These findings suggest that replacing UPF with minimally processed foods (MPF) during the preschool years may support healthier behavioral development, with potential benefits for long-term mental health. These findings also support ongoing policy actions that promote MPF and underscore the need for early-life dietary interventions.
Corresponding Author: To contact the corresponding author, Kozeta Miliku, MD, PhD, email kozeta.miliku@utoronto.ca.
(doi:10.1001/jamanetworkopen.2026.0434)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Physical Activity Before and During Pregnancy and Neurodevelopment in Early Childhood
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, TUESDAY, MARCH 3, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: The findings of this study suggest that maternal physical activity before and during pregnancy may be associated with optimized early neurodevelopment in offspring, particularly regarding motor function, highlighting the potential benefits of prenatal exercise beyond maternal health. Further investigations are required to find the physiological mechanisms explaining how maternal physical activity affects child neurodevelopment.
Corresponding Author: To contact the corresponding author, Chiharu Ota, MD, PhD, email chiharu.ota.e8@tohoku.ac.jp.
(doi:10.1001/jamanetworkopen.2026.0345)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Trends in Poverty and Birth Outcomes in the US
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 2, 2026
Media advisory: The full study is linked to this news release.
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About The Study: This study found stark disparities in birth outcomes by poverty status, with inequities growing for low birth weight in recent years. These disparities point to the need for more support during pregnancy and birth for low-income families. Antipoverty policies can provide needed resources to promote better maternal and child health, although the availability and generosity of these programs vary across states.
Corresponding Author: To contact the corresponding author, Emily C. Dore, PhD, MPH, MSW, email edore@hsph.harvard.edu.
(doi:10.1001/jamapediatrics.2026.0004)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Catheter Ablation and Oral Anticoagulation for Secondary Stroke Prevention in Atrial Fibrillation
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 2, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/jamaneurol.2026.0155?guestAccessKey=b2442349-ff15-43c6-b775-1eb2dfb6f7b5&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=030226
About The Study: In patients with atrial fibrillation and a recent stroke history, standard therapy plus catheter ablation did not significantly reduce the risk of the primary composite end point. The observed event rate was lower than anticipated, suggesting that the study was underpowered to detect clinically meaningful differences.
Corresponding Author: To contact the corresponding author, Kazumi Kimura, MD, PhD, email k-kimura@nms.ac.jp.
(doi:10.1001/jamaneurol.2026.0155)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Long COVID and Recovery Among US Adults
JAMA Network Open
EMBARGOED FOR RELEASE: 11 A.M. ET, MONDAY, MARCH 2, 2026
Media advisory: The full study is linked to this news release.
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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.
About The Study: In 2024, 8.3% of U.S. adults—an estimated 21.3 million—reported ever having long COVID (LC), among whom nearly 6 in 10 reported recovery, consistent with RECOVER initiative findings showing similar LC prevalence in 2023 and 2024 and longitudinal Veterans Affairs data demonstrating declining LC prevalence. Yet many adults, particularly those 35 years or older, continue to experience lasting symptoms. With no LC treatment demonstrating clear efficacy, greater investment in understanding biological mechanisms, including immunotypic differences between those who recover and those who do not, may provide insights into pathways of persistence and potential targets for intervention.
Corresponding Author: To contact the corresponding author, Harlan M. Krumholz, MD, SM, email harlan.krumholz@yale.edu.
(doi:10.1001/jamanetworkopen.2026.0374)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Low-Dose Lithium for Mild Cognitive Impairment
JAMA Neurology
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 2, 2026
Media advisory: The full study is linked to this news release.
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About The Study: This pilot randomized clinical trial established feasibility, confirmed safety and tolerability, and generated effect size estimates for future trials of low-dose lithium in mild cognitive impairment. None of the coprimary outcomes met the prespecified significance threshold.
Corresponding Author: To contact the corresponding author, Ariel G. Gildengers, MD, email ariel.gildengers@pitt.edu.
(doi:10.1001/jamaneurol.2026.0072)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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Within-Person Association Between Daily Screen Use and Sleep in Youth
JAMA Pediatrics
EMBARGOED FOR RELEASE: 11 A.M. (ET), MONDAY, MARCH 2, 2026
Media advisory: The full study is linked to this news release.
Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jamapediatrics/fullarticle/10.1001/jamapediatrics.2025.6490?guestAccessKey=6b556900-85d9-41ed-83bb-04c6b91e1b5a&utm_source=for_the_media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=030226
About The Study: Per the results of this systematic review and meta-analysis, daily screen time has a small but significant within-person correlation with later sleep onset; however, short-term daily fluctuations in screen time appear to have minimal impact on sleep duration, efficiency, or quality. Screen time may delay bedtime but is not inherently detrimental to other aspects of sleep health in youth, contrasting with between-person studies showing stronger adverse associations.
Corresponding Author: To contact the corresponding author, Matthew Bourke, PhD, email matthew.bourke1@deakin.edu.au.
(doi:10.1001/jamapediatrics.2025.6490)
Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.
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