Original Investigation

Nationwide Implementation of Multimodal Prehabilitation and Complications After Colorectal Cancer Surgery

JAMA Surgery 10.1001/jamasurg.2026.1519

May 20, 2026 at 11:00 AM EDT

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What is the association of a standardized 4-week supervised multimodal prehabilitation program with postoperative complications among unselected patients undergoing elective colorectal cancer resection in the Netherlands?In this large propensity score–matched cohort study of nearly 2400 patients undergoing colorectal cancer surgery in the Netherlands, participation in a 4-week standardized supervised multimodal prehabilitation program was associated with a reduction in both surgical and nonsurgical complications and a shorter hospital stay, regardless of age and American Society of Anesthesiologists score.Results suggest that a standardized multimodal prehabilitation program may not only reduce the occurrence of complications but also mitigate their adverse impact by improving preoperative functional capacity.

Corresponding Author: Gerrit D. Slooter, MD, PhD, Department of Surgery, Máxima Medical Center, De Run 4600, PO Box 7777, 5500 MB Veldhoven, the Netherlands (g.slooter@mmc.nl).

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