Electroencephalography Microstate Instability and Clinical Outcomes in Individuals at Clinical High Risk of Psychosis

Are electroencephalography (EEG) microstates associated with future clinical outcomes among young people at clinical high risk of psychosis (CHR)?In this case-control study of 460 individuals at CHR and 183 healthy control (HC) participants, temporal instability of brain microstate networks was associated with CHR status and was significantly increased in future converters to psychosis compared to nonconverters.The findings suggest that temporal instability of EEG microstates may serve as a putative prognostic biomarker of conversion to psychosis in individuals at CHR.

Corresponding Author: Daniel H. Mathalon, MD, PhD, Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, 4150 Clement St, 116D, San Francisco, CA 94121 (daniel.mathalon@ucsf.edu).

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