Viewpoint

Caffeine for Hypoxic-Ischemic Encephalopathy—Throwing Fuel on the Fire?

JAMA Pediatrics 10.1001/jamapediatrics.2026.1542

May 26, 2026 at 11:00 AM EDT

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This Viewpoint describes the need for more preclinical work to increase confidence that caffeine is safe and beneficial as a postnatal treatment for hypoxic-ischemic encephalopathy before clinical trials are conducted.

Corresponding Author: Nicola J. Robertson, MBChB, PhD, Institute for Women’s Health, University College London, London WC1E 6HX, United Kingdom (n.robertson@ucl.ac.uk).

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