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Circulating Tumor DNA in Head and Neck Cancer

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2026.2045

July 30, 2026 at 11:00 AM EDT

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Liquid biopsy targeting viral ctDNA is a promising biomarker in the diagnostic and surveillance settings across head and neck cancer types. Ongoing clinical trials will help elucidate how ctDNA can be implemented to monitor treatment response, assess MRD, and frame treatment decisions to adapt treatment via a precision oncology approach.

Corresponding Author: Sagar Kansara, MD, Department of Otolaryngology–Head and Neck Surgery, Louisiana State University Health Sciences Center, 533 Bolivar St, Ste 566, New Orleans, LA 70112 (skans1@lsuhsc.edu).

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