Original Investigation

Mechanisms Underlying an Enhanced Navigation-Based Intervention to Improve Timely Adjuvant Therapy

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2026.1891

July 23, 2026 at 11:00 AM EDT

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What are the mechanisms by which Navigation for Disparities and Untimely Radiation Therapy (NDURE), an enhanced navigation-based intervention, improves timely postoperative radiation therapy (PORT) vs usual care (UC) navigation among patients with head and neck cancer? In this secondary analysis of a randomized clinical trial including 145 patients, NDURE improved timely PORT vs UC by enhancing completion of a greater number of PORT-related care steps, such as preoperative radiation oncology consultation, preoperative dental evaluation, timely postoperative radiation oncology evaluation, and timely radiation planning. These PORT-related care steps, individually and as a group, are important targets to enhance the efficiency and efficacy of strategies to improve timely PORT.

Corresponding Author: Evan M. Graboyes, MD, MPH, Department of Otolaryngology–Head graboyes@musc.edu).

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