Smell and Taste Disturbances Among Glucagon-Like Peptide-1 Receptor Agonist Users

Is long-term use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) associated with an increased risk of smell and taste disturbances?In this cohort study, 438 474 patients with documented type 2 diabetes (T2D) were matched to control patients with T2D and no documented exposure to GLP-1 RAs. The GLP-1 RA cohort was associated with a higher risk of new smell and taste disturbances over 2 years of follow-up.These findings suggest that GLP-1 RAs may be associated with an increased risk of smell and taste disturbances, highlighting the need for increased awareness among both clinicians and users.

Corresponding Author: Nir Zontag, BSc, Hadassah Medical Center, Faculty of Medicine, Hebrew University, Israel Hadassah Ein Kerem Campus, Jerusalem, 9112001, Israel (nir.zontag@mail.huji.ac.il).

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