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Imaging-Detected Extranodal Extension in p16-Positive Oropharyngeal Cancer

JAMA Otolaryngology–Head & Neck Surgery 10.1001/jamaoto.2026.0932

August 27, 2026 at 11:00 AM EDT

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This study showed that the updated TNM9 clinical nodal schema, in which patients with iENE-positive disease are upstaged 1 stratum from their TNM8 clinical N category, discriminates better than the TNM8 category between patients.

Corresponding Author: Shlomo A. Koyfman, MD, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195 (koyfmas@ccf.org).

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