Original Investigation

Longitudinal Trajectories of 3-Dimensional Eye Shape and Pathological Sequelae in High Myopia

JAMA Ophthalmology 10.1001/jamaophthalmol.2026.3684

September 03, 2026 at 11:00 AM EDT

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Highly myopic globes followed age- and geometry-associated trajectories linked to outcomes beyond axial elongation. These 2–time-point findings potentially support 3D shape analysis as a candidate framework for individualized surveillance, pending prospective validation.

Corresponding Authors: Shida Chen, MD, PhD (chenshd3@mail.sysu.edu.cn), and Wei Wang, MD, PhD (wangwei@gzzoc.com), State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University; Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science; Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 510623, China.

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