Combined Limbal Epithelial and Stromal Cell Transplant for Aniridia-Related Keratopathy

Is Real Architecture for 3D Tissues–Ocular Surface (RAFT-OS) transplant (combined limbal epithelial and stromal cell transplant) safe and feasible in adults with advanced aniridia-related keratopathy (ARK)? In this nonrandomized clinical trial including 9 participants, RAFT-OS transplant was associated with a mean Ocular Surface Score reduction of 3.6 points at 3 months, with partial maintenance of this reduction at 12 months and no substantial safety concerns compared with untreated fellow eyes. While these findings suggest that RAFT-OS transplant offers a potential regenerative treatment approach for advanced ARK, further evaluation in a larger cohort with randomized controls is needed to determine the precise efficacy and safety of this intervention.

Corresponding Author: Abigail Eve Kaye, MBChB, PhD, UCL Institute of Ophthalmology, University College London, 1-43 Bath St, London EC1V 9EL, United Kingdom (abigail.kaye@ucl.ac.uk).

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