JAMA Ophthalmology Clinical Challenge

Optic Disc and Macular Edema in a Previously Healthy TeenagerOptic Disc and Macular Edema in a Previously Healthy Teenager—CaseOptic Disc and Macular Edema in a Previously Healthy Teenager—Diagnosis

JAMA Ophthalmology 10.1001/jamaophthalmol.2026.1466

May 21, 2026 at 11:00 AM EDT

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A 16-year-old female presents to your clinic with 5 weeks of blurry vision in the left eye, headaches, weight loss, fevers, chills, night sweats, fatigue, generalized weakness, dizziness, chest pain, and shortness of breath. What would you do next?

Corresponding Author: Danny A. Mammo, MD, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Ave, i-32, Cleveland, OH 44195 (danny.mammo24@gmail.com).

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