Original Investigation

Treatment Delays in Early Age–Onset Colorectal Cancer

JAMA Oncology 10.1001/jamaoncol.2026.1335

June 04, 2026 at 11:00 AM EDT

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What are the demographic and clinical patterns in early age–onset colorectal cancer (EOCRC) that determine poor outcomes in a heterogeneous population?In this population-based cross-sectional study of 112 672 patients with colorectal cancer in Texas, 12 079 (11%) of whom had EOCRC, patients with EOCRC were more likely to be Hispanic, have left-sided or rectal tumors, and present with advanced-stage disease. Treatment delays were associated with worse overall survival, and the presence of a language barrier was identified as a key social risk factor contributing to treatment delays in this population.The presence of a language barrier is a potential target for future interventions in patients with EOCRC.

Corresponding Author: Alex C. Kim, MD, PhD, Department of Surgery, Division of Surgical Oncology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 (alex.kim@utsouthwestern.edu).

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