Plasma Biomarkers for Neocortical Tau Burden

This multicohort study demonstrated how including additional plasma proteins significantly enhanced the performance of p-tau217 in predicting advanced tau pathology among amyloid-positive individuals. This suggests a multiprotein approach may offer a viable and scalable alternative to tau PET staging in clinical or research settings.

Corresponding Author: Nicholas J. Ashton, PhD, Banner Sun Health Research Institute, 10515 W Santa Fe Dr, Sun City, AZ 85351 (nicholas.ashton@bannerhealth.com).

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