Research Letter

IL-6 Receptor Blockade as Rescue Therapy in Acute Attacks of MOGAD and AQP4+NMOSD

JAMA Neurology 10.1001/jamaneurol.2026.1850

June 15, 2026 at 11:00 AM EDT

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This case series describes multicenter experience with interleukin 6 (IL-6) receptor blockers used during attacks in aquaporin 4–immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4+NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD).

Corresponding Author: Ilya Kister, MD, NYU Multiple Sclerosis Comprehensive Care Center, Department of Neurology, New York University Grossman School of Medicine, 240 E 38th St, 13th Floor, New York, NY 10016 (ilya.kister@nyulangone.org).

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