Original Investigation

Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury

JAMA Network Open 10.1001/jamanetworkopen.2026.32555

September 08, 2026 at 11:00 AM EDT

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In this secondary analysis of a multicenter randomized clinical trial, a liberal RBCT strategy was associated with a lower risk than a restrictive RBCT strategy of unfavorable neurological outcome at 180 days among patients with TBI. These findings should be interpreted with caution in light of the inherent uncertainty of the estimate.

Corresponding Author: Elisa Gouvêa Bogossian, MD, PhD, Department of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070 Brussels, Belgium (elisagobog@gmail.com).

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