HLA-A*32:01 and Lamotrigine-Induced Drug Reaction With Eosinophilia and Systemic Symptoms

Are any HLA alleles associated with lamotrigine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) in a US population? In this matched case-control study of 29 case and 290 control participants, HLA-A*32:01 was strongly associated with lamotrigine-induced DRESS. These findings suggest that HLA-A*32:01 screening may help identify patients at risk for lamotrigine-induced DRESS, but it is absent from current commercial pharmacogenomic panels for preventing severe cutaneous adverse reactions.

Corresponding Author: Elizabeth J. Phillips, MD, Center for Drug Safety and Immunology, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN 37232 (elizabeth.j.phillips@vumc.org).

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