Original Investigation

Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts

JAMA Network Open 10.1001/jamanetworkopen.2026.30964

August 26, 2026 at 11:00 AM EDT

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In this cohort study of parental longevity, centenarians’ offspring exhibited delayed onset of mortality and several morbidities as well as reduced age-associated risk for several morbidities. These findings support the value of using this group as a research model for identifying factors that may promote healthy aging and the suitability of parental longevity as a criterion in prospective studies of resilience.

Corresponding Author: Eric R. Reed, PhD, Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine, 1300 Morris Park Ave, Belfer Building, Ste 702, Bronx, NY 10461 (eric.reed@einsteinmed.edu).

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