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Original Investigation

Androgen-Modulating Drugs and Severe Complications After ST-Elevation Myocardial Infarction

JAMA Network Open 10.1001/jamanetworkopen.2026.30774

August 25, 2026 at 11:00 AM EDT

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In this cohort study of men with PCI-treated STEMI, use of 5αRI but not ADT was associated with a lower risk of severe complications. These results warrant further research into the role of androgens and drugs that affect androgen levels in the acute phase of STEMI.

Corresponding Author: Hannah Colldén, PhD, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Box 100, 405 30 Göteborg, Sweden (hannah.collden@gu.se).

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